|6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶|CsnPharm

CAS No.: 866405-64-3

6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine Catalog No. CSN13424

Synonyms: Compound C;BML-275;CpdC

Dorsomorphin is a selective AMPK inhibitor with Ki value of 109 nM.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 AMPK

Ki:109nM
描述Dorsomorphin, known as compound C, is a reversible selective ATP-competitive inhibitor of AMPK with Ki of 109 nM. Dorsomorphin can also inhibit the bone morphogenic protein (BMP) signaling and do not effect the expression of several structurally related kinases including ZAPK, SYK, PKCq, PKA, and JAK3^[3]. In addition, dorsomorphin could stimulate the oxidation of long chain fatty acids independently in adipocytes by increasing carnitine palmitoyltransferase-1 (CPT1) activity^[4] and remarkly reduce the adipogenic Differentiation of 3T3-L1 cells at 10 μM^[5]. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway^[6]. In vivo, dorsomorphin induces dorsalization in zebrafish embryos and the differentiation of osteoblast^[7].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
mouse C2C12 cells	4 μM	Function assay	-	Inhibition of BMPR1-mediated osteoblast differentiation in BMP4-stimulated mouse C2C12 cells assessed as decrease in alkaline phosphatase level at 4 uM by spectrophotometry	18026094

动物研究
剂量
Mice: 3 mg/kg - 12 mg/kg^[3] (i.p.) Rat: 0.2 mg/kg^[4] (i.v.)

给药途径
i.p., i.v.

动物研究
剂量	Mice: 3 mg/kg - 12 mg/kg^[3] (i.p.) Rat: 0.2 mg/kg^[4] (i.v.)
给药途径	i.p., i.v.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5032 mL
- 12.5160 mL
- 25.0320 mL
- 5 mM
- 0.5006 mL
- 2.5032 mL
- 5.0064 mL
- 10 mM
- 0.2503 mL
- 1.2516 mL
- 2.5032 mL

技术信息

CAS号

866405-64-3

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H25N5O

运输

蓝冰

分子量

399.49

别名

Compound C;BML-275;CpdC

溶解度

DMSO	2.0 mg/mL (5.0 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+water	0.04 mg/mL	clear
PO	0.5% CMC-Na	55 mg/mL	suspension

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine Catalog No. CSN13424

靶点选择性

请登录您的专属账户

确认信息